This observational analysis examined 13,027 CABG patient records using propensity score-adjusted models to assess associations between preoperative HDL-C and postoperative complications. Among patients with HDL-C measurements, higher HDL-C was associated with less AKI (OR 0.92, p=0.04; n=3,716). In patients aged ≥65 years, higher HDL-C was associated with less delirium (OR 0.80, p=0.046) and AKI-associated delirium (OR 0.58, p=0.007; n=2,120). Higher HDL-C was not significantly associated with less delirium in the entire cohort (p=0.17), and the authors characterized the findings as hypothesis-generating.
Preoperative HDL-C may warrant further investigation as a marker of postoperative AKI and delirium risk, particularly in older CABG patients. These associations do not establish a protective effect.
Study limitation: Substantial missing HDL-C data create potential selection bias despite adjustment; the abstract does not specify the HDL-C increment underlying reported odds ratios.
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