This retrospective, single-centre study included 64 ICU patients with intermediate-high- or high-risk pulmonary embolism during 2021–2022. Among 57 initially intermediate-high-risk patients, four (7.0%) progressed to high-risk PE. Baseline sPESI was higher in those who progressed than in those remaining haemodynamically stable (3.5 versus 2.0; P=.029). Exploratory Firth penalised logistic regression associated each one-point higher baseline sPESI with greater odds of progression (OR 2.75; 95% confidence interval 1.23–8.44; P=.012). In-hospital mortality in the overall cohort was 7.8%.
Higher baseline sPESI was associated with deterioration among initially intermediate-high-risk ICU patients with PE. These exploratory findings do not establish a validated prediction rule for clinical decisions.
Study limitation: The retrospective, single-centre cohort had only four progression events, limiting precision and confidence in the exploratory regression findings.
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