A mixed retrospective and prospective cohort study examined the blood pressure response index (BPRI), defined as mean arterial pressure divided by vasoactive inotropic score, in pneumonia-associated shock. The retrospective cohort included 618 patients and the prospective cohort 65 patients. Higher BPRI was associated with lower mortality risk in the retrospective analysis (adjusted hazard ratio 0.843; 95% confidence interval 0.811–0.877). For 30-day mortality, BPRI discrimination was numerically higher than either component alone, with an area under the curve of 0.7404 (95% interval 0.7018–0.7790), and prospective findings were consistent.
BPRI may offer prognostic information in pneumonia-associated septic shock. These observational findings do not establish that targeting BPRI improves outcomes or that it should guide vasopressor management.
Study limitation: The prospective cohort was small, and the abstract does not specify the BPRI measurement timing or the adjustment variables.
AI-generated from the published abstract with automated source checks. For research discovery; consult the original paper before applying findings.