This retrospective cohort externally validated SLANT for predicting in-hospital mortality in 451 comatose adult out-of-hospital cardiac arrest survivors receiving targeted temperature management at three Taiwanese tertiary hospitals during 2016–2023. Overall, 300 patients (66.5%) died during hospitalisation. The score had an area under the receiver operating characteristic curve of 0.746 (95% confidence interval 0.696–0.796), with acceptable calibration, particularly at moderate to high risk. At a score threshold of ≥14, sensitivity was 65.7%, specificity 78.2%, and positive predictive value 85.7%.
SLANT showed reasonable mortality discrimination in this external cohort. These findings support further evaluation for contextual risk stratification, not its use as a standalone determinant of individual prognosis or care decisions.
Study limitation: Retrospective validation in three Taiwanese tertiary hospitals limits generalisability beyond similar patients and care settings.
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