This retrospective review compared 4F-PCC at 25 versus 12.5 units/kg after a cardiac-surgery dosing protocol change, including 31 and 11 patients, respectively. The primary endpoint, receiving at least three packed red blood cell transfusions within 24 hours, occurred in 15 versus three patients (P = .299). Thromboembolic events within 14 days occurred in 22.6% versus 0%, respectively (P = .161), leaving considerable uncertainty about this numerical difference. No statistically significant differences were reported in additional haemostatic agent use, hospital length of stay or mortality.
This small observational comparison does not establish equivalent effectiveness or safety between dosing strategies. The numerical thromboembolic difference is inconclusive and warrants further study.
Study limitation: The small, unequal groups and retrospective comparison following a protocol change limit precision and causal interpretation.
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