This observational study measured circulating 12,13-diHOME, a brown-adipose-tissue-associated lipid, in 74 patients from 6 hours through 7 days after return of spontaneous circulation. Levels were increased in patients receiving targeted temperature management at 33°C and were associated with survival. Concentrations peaked during the first 12–48 hours and fell below the initial post-resuscitation level by day 7. Higher levels were also associated with more mature and fewer immature neutrophils, while a subset of patients with higher levels showed a specific phospholipid signature.
These findings identify a survival-associated biomarker in post-arrest temperature management. They do not establish that brown adipose tissue activity mediates treatment benefit or that biomarker-guided temperature management improves outcomes.
Study limitation: The abstract provides no survival effect estimate, uncertainty interval, adjustment details, or survival assessment timepoint.
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