This retrospective single-centre registry analysis examined preoperative lipids and 28-day mortality after cardiac surgery with cardiopulmonary bypass. Among 1,986 patients with lipid measurements, 64 (3.2%) died within 28 days. After adjustment, LDL-C was not associated with mortality (adjusted odds ratio 0.803, 95% confidence interval 0.595-1.084); the borderline total cholesterol association did not survive multiplicity correction. Lipid measures showed poor discrimination, with areas under the curve of 0.57-0.62, and added no prognostic information beyond EuroSCORE 2, despite associations between lower lipid concentrations and mortality in unadjusted analyses.
Preoperative lipid measurements did not improve mortality prognostication beyond EuroSCORE 2 in this cohort. These observational findings do not establish a causal role for low cholesterol.
Study limitation: This single-centre retrospective analysis included lipid measurements for only 1,986 of 10,017 patients, limiting representativeness and leaving potential selection bias.
AI-generated from the published abstract with automated source checks. For research discovery; consult the original paper before applying findings.