CS-MORT-6 was developed in adults with cardiogenic shock to predict subsequent in-hospital mortality at a 24-hour landmark; 892 deaths occurred among 2694 ICU survivors at that landmark. External validation included 1047 patients from 117 hospitals. The integer score had an external AUROC of 0.759 (95% CI, 0.729–0.790), but overpredicted mortality on average. Within EHR-derived SCAI stages, mortality differed by 20–47 percentage points between the lowest and highest score tertiles in MIMIC-IV, with a similar pattern in eICU, suggesting additional risk stratification beyond stage alone.
CS-MORT-6 showed moderate external discrimination and differentiated mortality risk within EHR-derived SCAI stages. These findings support further prognostic evaluation, not score-directed treatment decisions.
Study limitation: Predictions apply to patients alive in the ICU at 24 hours; repeated scoring and real-time performance require prospective evaluation.
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