This single-center retrospective study evaluated immunonutritional indices measured within 24 hours of ICU admission in 444 adults after return of spontaneous circulation following out-of-hospital cardiac arrest. Non-survivors had lower Prognostic Nutritional Index (PNI), higher cholesterol-modified PNI (CPNI), and higher Controlling Nutritional Status (CONUT) scores than survivors. In separate adjusted models, mortality odds ratios were 0.64 per 10-point PNI increase, 1.25 per 10-point CPNI increase, and 1.24 per one-point CONUT increase. Discrimination for ICU mortality was modest, with AUCs of 0.689 for PNI, 0.631 for CPNI, and 0.681 for CONUT.
These routine laboratory-derived indices were associated with ICU mortality after cardiac arrest, but their modest discrimination and retrospective evaluation leave their clinical prognostic utility uncertain.
Study limitation: The single-center retrospective design limits generalizability; the abstract reports no confidence intervals for adjusted associations.
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